Grape seed extract explained: what it is and safety

Grape seed extract is made from wine grape seeds. It contains compounds called proanthocyanidins, according to the NIH. Three products we reviewed list grape seed extract, but none prints its individual amount, and each lists it within a 200 mg proprietary blend.

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What it is
Plant
In the products we reviewed
3, none prints the amount

What grape seed extract is

  • Grape seed extract is made from wine grape seeds.1
  • Grape seed extract has the Latin name Vitis vinifera.1
  • Grape seed extract contains compounds called proanthocyanidins.1
  • Grape seed extract is generally well tolerated when taken by mouth or applied to the skin.1

How much grape seed extract each product gives

Per serving, as each label prints it

Amount not printed: the dashed line shows the most it can be, the whole blend

GlucoTonicNot printed · at most 200 mg
Sugar DefenderNot printed · at most 200 mg
Glyco HarmonyNot printed · at most 200 mg

Before you take it

If you take medicines

Any medicine
Check with your health care provider before combining grape seed extract with any medicine because some herbs and medicines interact in harmful ways.1

Ask a doctor first

  • Little is known about the safety of grape seed extract during pregnancy or breastfeeding.1

These statements have not been evaluated by the FDA. A supplement is not a medicine.

The 3 products we reviewed that list grape seed extract

ProductForm and servingGrape seed extract per servingOur scorePrice a bottleBuy
GlucoTonic#1 in blood sugar supportLiquid drops1 mlNot printedIn a 200 mg proprietary blend9.9$49Check price
Sugar Defender#3 in blood sugar supportLiquid drops1 mlNot printedIn a 200 mg proprietary blend9.5$49Check price
Glyco Harmony#5 in blood sugar supportLiquid drops1 mlNot printedIn a 200 mg proprietary blend9.3$49Check price
Prices checked Oct 5, 2026

Questions people ask

What is grape seed extract?

Grape seed extract is an extract made from wine grape seeds. The NIH lists its Latin name as Vitis vinifera and says it contains compounds called proanthocyanidins.

Is grape seed extract safe?

Grape seed extract is generally well tolerated when taken by mouth or applied to the skin, according to the NIH.

Can I take grape seed extract during pregnancy or breastfeeding?

Little is known about the safety of grape seed extract during pregnancy or breastfeeding. Ask a clinician before starting.

What should I check before taking grape seed extract?

Check with a clinician before combining grape seed extract with any medicine. Some herbs and medicines interact in harmful ways.

Which products we reviewed contain grape seed extract, and how much do they hold?

GlucoTonic, Sugar Defender and Glyco Harmony list grape seed extract, but none prints its individual amount. All three are liquid drops with a 1 ml serving, and each lists it inside a 200 mg proprietary blend. That amount is for the whole blend, not grape seed extract alone.

Also in these products

Sources

The products, amounts and prices come from each product's label and checkout, as its review shows them. AI drafts our pages from listed sources, figures are checked against them, and we have not tried the products.

  1. 1NIH National Center for Complementary and Integrative Health, Grape Seed Extractnccih.nih.gov/healthchecked