Cayenne pepper explained: what it is and side effects

Capsaicin comes from chili peppers and makes them taste hot. The NIH says capsaicinoids give chili peppers their sharp flavor, and capsaicin is the most abundant and most studied of them. Five products we reviewed list cayenne pepper (capsicum), and none prints its individual amount.

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What it is
Plant
Amounts the NIH names
2 to 4 mg of capsaicinoids a day in a 12-week trial
In the products we reviewed
5, none prints the amount

What cayenne pepper (capsicum) is

  • Capsaicin comes from chili peppers and makes them taste hot.1
  • Capsaicinoids give chili peppers their sharp flavor, and capsaicin is the most abundant and most studied of them.2
  • Studies have used from 0.2 mg of capsaicinoids in a single meal up to 33 mg a day for 4 weeks, from chili powder, chili foods or chili capsules.2
  • Capsaicin is considered safe at up to 33 mg a day for 4 weeks or 4 mg a day for 12 weeks.1

How much cayenne pepper (capsicum) each product gives

Per serving, as each label prints it, against the amounts the NIH names

NIH: 2 mg to 4 mg per dose

Amount not printed: the dashed line shows the most it can be, the whole blend

GlucoTonicNot printed · at most 200 mg
FitSpressoNot printed · at most 56 mg
Sugar DefenderNot printed · at most 200 mg
Glyco HarmonyNot printed · at most 200 mg
GlucoTrustNot printed · at most 208 mg

Before you take it

Ask a doctor first

  • Capsaicin can cause stomach pain, burning sensations, nausea and bloating.1
  • Capsaicinoid supplements might raise insulin levels in the blood and lower HDL cholesterol levels.2

These statements have not been evaluated by the FDA. A supplement is not a medicine.

The 5 products we reviewed that list cayenne pepper (capsicum)

ProductForm and servingCayenne pepper (capsicum) per servingOur scorePrice a bottleBuy
GlucoTonic#1 in blood sugar supportLiquid drops1 mlNot printedIn a 200 mg proprietary blend9.9$49Check price
FitSpresso#2 in weight loss supportCapsules1 capsuleNot printedIn a 56 mg proprietary blend9.5$39Check price
Sugar Defender#3 in blood sugar supportLiquid drops1 mlNot printedIn a 200 mg proprietary blend9.5$49Check price
Glyco Harmony#5 in blood sugar supportLiquid drops1 mlNot printedIn a 200 mg proprietary blend9.3$49Check price
GlucoTrust#6 in blood sugar supportCapsules1 capsuleNot printedIn a 207.7 mg proprietary blend8.9$49Check price
Prices checked Oct 5, 2026

Questions people ask

What is in cayenne pepper that makes it hot?

Capsaicin makes chili peppers taste hot. The NIH says it is the most abundant and most studied of the capsaicinoids, which give chili peppers their sharp flavor.

How much cayenne pepper should I take per day?

The NIH amounts here refer to capsaicinoids, not a daily serving of cayenne pepper. It describes 2 to 4 mg of capsaicinoids a day in a 12-week trial. Ask a clinician before starting a supplement.

Is a capsaicin supplement safe?

The NIH considers capsaicin safe at up to 33 mg a day for 4 weeks or 4 mg a day for 12 weeks. Capsaicin can cause stomach pain, burning sensations, nausea and bloating. Ask a clinician before starting.

Which supplements we reviewed contain cayenne pepper?

GlucoTonic, FitSpresso, Sugar Defender, Glyco Harmony and GlucoTrust list cayenne pepper (capsicum), but none prints its individual amount. GlucoTonic, Sugar Defender and Glyco Harmony place it inside a 200 mg proprietary blend. FitSpresso lists a 56 mg blend, and GlucoTrust lists a 207.7 mg blend, so these figures describe the whole blends, not cayenne pepper alone.

Which cayenne pepper capsules and drops did we review?

FitSpresso and GlucoTrust are capsules, while GlucoTonic, Sugar Defender and Glyco Harmony are liquid drops. The listed serving is 1 capsule for each capsule product and 1 ml for each liquid product.

Also in these products

Sources

The products, amounts and prices come from each product's label and checkout, as its review shows them. AI drafts our pages from listed sources, figures are checked against them, and we have not tried the products.

  1. 1NIH Office of Dietary Supplements, Dietary Supplements for Weight Loss, Fact Sheet for Consumersods.od.nih.gov/factsheetschecked
  2. 2NIH Office of Dietary Supplements, Dietary Supplements for Weight Loss, Fact Sheet for Health Professionalsods.od.nih.gov/factsheetschecked