Goldenseal explained: what it is and where it grows

According to the NIH, goldenseal is a plant with a bright yellow underground stem called a rhizome that grows naturally in the northeastern United States and southeastern Canada. One product we reviewed lists goldenseal, and no labels print a separate amount for it.

What it is
Plant
In the products we reviewed
1, its label does not print the amount

What goldenseal is

  • Goldenseal is also called yellow root, goldenroot, and yellow pucoon.1
  • Goldenseal grows naturally in the northeastern United States and southeastern Canada.1
  • Goldenseal has a bright yellow underground stem called a rhizome.1
  • Goldenseal root contains berberine and other compounds called isoquinoline alkaloids.2
  • Goldenseal is grown commercially but is expensive to cultivate.1

How much goldenseal each product gives

Per serving, as each label prints it

Amount not printed: the dashed line shows the most it can be, the whole blend

Max VitalizeNot printed · at most 176 mg

Before you take it

If you take medicines

medications
Goldenseal may change how your body processes many medications.1
metformin
Combining goldenseal extract with metformin decreased metformin levels by about 25 percent in healthy adults.1

Ask a doctor first

  • Do not use goldenseal during pregnancy or breastfeeding, and do not give it to infants.1
  • The safety of taking goldenseal for longer periods is uncertain.1
  • Ask your health care provider before using goldenseal if you take any medicine.1

These statements have not been evaluated by the FDA. A supplement is not a medicine.

The product we reviewed that lists goldenseal

ProductForm and servingGoldenseal per servingOur scorePrice a bottleBuy
Max Vitalize#3 in men's health supportCapsules2 capsulesNot printedIn a 176 mg proprietary blend9.3$49Check price
Prices checked Oct 11, 2026

Questions people ask

What is goldenseal root?

Goldenseal root contains berberine and other compounds called isoquinoline alkaloids, according to the NIH. Goldenseal is also called yellow root, goldenroot, and yellow pucoon.

Does goldenseal have interactions?

Yes. Goldenseal may change how your body processes many medications. Ask a clinician before starting goldenseal if you take any medication.

What should I know about goldenseal side effects?

Do not use goldenseal during pregnancy or breastfeeding, and do not give it to infants. The safety of taking goldenseal for longer periods is uncertain. Ask a clinician before starting.

How long can you take goldenseal?

The safety of taking goldenseal for longer periods is uncertain. Ask a clinician before starting goldenseal.

Which supplements we reviewed contain goldenseal?

Max Vitalize lists goldenseal. Its separate amount is not printed because it is inside a 176 mg proprietary blend. The serving is 2 capsules.

Sources

The products, amounts and prices come from each product's label and checkout, as its review shows them. AI drafts our pages from listed sources, figures are checked against them, and we have not tried the products.

  1. 1NIH National Center for Complementary and Integrative Health, Goldensealnccih.nih.gov/healthchecked
  2. 2NIH LactMed, Goldensealncbi.nlm.nih.gov/bookschecked